Arrowsmith - Sinclair Lewis [215]
He assented, not very pleasantly.
He began to work on the cause of influenza with a half-heartedness almost magnificent. In the hospitals he secured cultures from cases which might be influenza and might be bad colds — no one was certain just what the influenza symptoms were; nothing was clean cut. He left most of the work to his assistants, occasionally giving them sardonic directions to “put on another hundred tubes of the A medium — hell, make it another thousand!” and when he found that they were doing as they pleased, he was not righteous nor rebuking. If he did not guiltily turn his hand from the plow it was only because he never touched the plow. Once his own small laboratory had been as fussily neat as a New Hampshire kitchen. Now the several rooms under his charge were a disgrace, with long racks of abandoned test-tubes, many half-filled with mold, none of them properly labeled.
Then he had his idea. He began firmly to believe that the Rockefeller investigators had found the cause of flu. He gushed in to Holabird and told him so. As for himself, he was going back to his search for the real nature of phage.
Holabird argued that Martin must be wrong. If Holabird wanted the McGurk Institute — and the Director of the McGurk Institute — to have the credit for capturing influenza, then it simply could not be possible that Rockefeller was ahead of them. He also said weighty things about phage. Its essential nature, he pointed out, was an academic question.
But Martin was by now too much of a scientific dialectician for Holabird, who gave up and retired to his den (or so Martin gloomily believed) to devise new ways of plaguing him. For a time Martin was again left free to wallow in work.
He found a means of reproducing phage on dead bacteria by a very complicated, very delicate use of partial oxygen-carbon dioxide tension — as exquisite as cameo-carving, as improbable as weighing the stars. His report stirred the laboratory world, and here and there (in Tokio, in Amsterdam, in Winnemac) enthusiasts believed he had proven that phage was a living organism; and other enthusiasts said, in esoteric language with mathematical formulae, that he was a liar and six kinds of a fool.
It was at this time, when he might have become a Great Man, that he pitched over most of his own work and some of the duties of being Joyce’s husband to follow Terry Wickett, which showed that he lacked common sense, because Terry was still an assistant while he himself was head of a department.
Terry had discovered that certain quinine derivatives when introduced into the animal body slowly decompose into products which are highly toxic to bacteria but only mildly toxic to the body. There was hinted here a whole new world of therapy. Terry explained it to Martin, and invited him to collaborate. Buoyant with great things they got leave from Holabird — and from Joyce — and though it was winter they went off to Birdies’ Rest, in the Vermont hills. While they snowshoed and shot rabbits, and all the long dark evenings while they lay on their bellies before the fire, they ranted and planned.
Martin had not been so long silk-wrapped that he could not enjoy gobbling salt pork after the northwest wind and the snow. It was not unpleasant to be free of thinking up new compliments for Joyce.
They had, they saw, to answer an interesting question: Do the quinine derivatives act by attaching themselves to the bacteria, or by changing the body fluids? It was a simple, clear, definite question which required for answer only the inmost knowledge of chemistry and biology, a few hundred animals on which to experiment, and perhaps ten or twenty or a million years of trying and failing.
They decided to work with the pneumococcus, and with the animal which should most nearly reproduce human pneumonia. This meant the monkey, and to murder monkeys is expensive and rather