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By Root 2426 0

produced; synthetic melatonin supplements were part of the longevity treatment, but of course it would be better to stop the calcification from occurring in the first place, for it probably had other effects. Then there was a clear growth in the number of neurofibrillary tangles, which were protein filament aggregates that grew between neurons, exerting physical pressure on them, perhaps the analogue of the pressure Maya reported feeling during her presque vus, who could say. Then again beta-amyloid protein accumulated in the cerebral blood vessels and in the extracellular space around nerve terminals, again impeding function. And pyramidal neurons in the frontal cortex and hippocampus accumulated calpain, which meant they were vulnerable to calcium influxes, which damaged them. And these were nondividing cells, the same age as the organism itself; damage to them was permanent, as during Sax’s stroke. He had lost a lot of his brain in that incident, he didn’t like to think of it. And the ability of the molecules in these nondividing cells to replace themselves could also be damaged, a smaller but over time equally significant loss. Autopsies of people over two hundred who had died of the quick decline regularly showed serious calcification of the pineal gland, coupled with increases in calpain levels in the hippocampus. And the hippocampus and calpain levels generally were both implicated in some of the leading current models of how the memory worked. It was an interesting connection.

But all inconclusive. And no one was going to solve the mystery by literature review alone. But the experiments that might clear things up were not practical, given the inaccessibility of the living brain. You could kill chicks and mice and rats and dogs and pigs and lemurs and chimps, you could kill individuals of every species in creation, dissect the brains of their fetuses and embryos as well, and still never find what you were looking for; for it was autopsy itself that was insufficient to the task. And the various live scans were likewise insufficient to the task, as the processes involved were either more fine-grained than the scans could perceive, or more holistic, or more combinatorial, or, probably, all three at once.

Still, some of the experiments and the resultant modeling were suggestive; calpain buildup seemed to alter brain-wave function, for instance; and this fact and others gave him ideas for further investigation. He began to read intensively in the literature on the effects of calcium-binding protein levels, on corticosteroids, on the calcium currents in the hippocampal pyramidal neurons, and on the calcification of the pineal gland. It appeared there were synergistic effects that might impact both memory and general brain-wave function, indeed all bodily rhythms, including heart rhythms. “Was Michel experiencing any memory troubles?” Sax asked Maya. “Perhaps feeling that he had lost entire trains of thought— even very useful trains of thought?”

Maya shrugged. By now Michel was almost a year gone. “I can’t remember.”

It made Sax nervous. Maya seemed in retreat, her memory worse every day. Even Nadia could do nothing for her. Sax met her down on the corniche more and more frequently, it was a habit they both clearly must have enjoyed, though they never spoke of that; they simply sat, ate a kiosk meal, watched the sunset and pulled up their color charts to see if they would catch another new one. But if it weren’t for the notations they made on the charts, neither of them would have been sure whether the colors they saw were new or not. Sax himself felt that he was experiencing his blankouts more frequently, perhaps some four to eight a day, although he couldn’t be sure. He took to keeping his AI running a sound recorder permanently, activated by voice; and rather than try to describe his complete train of thought, he just spoke a few words that he hoped would later key a fuller recollection of what he had been thinking. Thus at the end of the day he would sit down apprehensively or hopefully, and listen to what the AI