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Blue Mars - Kim Stanley Robinson [51]

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named for a characteristic abnormal long wave in the electrocardiogram. He called up Ann’s genome, and instructed the AI to run a search in the relevant regions of chromosomes 3, 7, and 11. In the gene called HERG, in her chromosome 7, the AI identified a small mutation: one reversal of adenine-thymine and guanine-cytosine. Small, but HERG contained instructions for the assembly of a protein that served as a potassium ion channel in the surface of heart cells, and these ion channels acted as a switch to turn off contracting heart cells. Without this brake the heart could go arrhythmic, and beat too fast to pump blood effectively.

Ann also appeared to have another problem, with a gene on chromosome 3 called SCN5A. This gene encoded a different regulatory protein, which provided a sodium ion channel on the surface of heart cells. This channel functioned as an accelerator, and mutations here could add to the problem of rapid heartbeat. Ann had a CG bit missing.

These genetic conditions were rare, but for the diagnostic AI that was not an issue. It contained a symptomology for all known problems, no matter how rare. It seemed to consider Ann’s case to be fairly straightforward, and it listed the treatments that existed to counteract the problems presented by the condition. There were a lot of them.

One of the treatments suggested was the recoding of the problem genes, in the course of the standard gerontological treatments. Persistent gene recodings through several longevity treatments should erase the cause of the problem right at the root, or rather in the seed. It seemed strange that this hadn’t been done already, but then Sax saw that the recommendation was only about two decades old; it came from a period after the last time Ann had taken the treatments.

For a long time Sax sat there, staring at the screen. Much later he got up. He began to inspect the Reds’ medical clinic, instrument by instrument, room by room. The nursing attendants let him wander; they thought he was distraught.

This was a major Red refuge, and it seemed likely to him that one of the rooms might contain the equipment necessary to administer the gerontological treatments. Indeed it was so. A small room at the back of the clinic appeared to be devoted to the process. It didn’t take much: a bulky AI, a small lab, the stock proteins and chemicals, the incubators, the MRIs, the IV equipment. Amazing, when you considered what it did. But that had always been true. Life itself was amazing: simple protein sequences only, at the start, and yet here they were.

So. The main AI had Ann’s genome record. But if he ordered this lab to start synthesizing her DNA strands for her (adding the recodings of HERG and SCN5A) the people here would surely notice. And then there would be trouble.

He went back to his tiny room to make a coded call to Da Vinci. He asked his associates there to start the synthesis, and they agreed without any questions beyond the technical ones. Sometimes he loved those saxaclones with all his heart.

After that it was back to waiting. Hours passed; more hours; more hours. Eventually several days had passed, with no change in Ann. The doctor’s expression grew blacker and blacker, though she said nothing more about unhooking Ann. But it was in her eye. Sax took to sleeping on the floor in Ann’s room. He grew to know the rhythm of her breathing. He spent a lot of time with a hand cradling her head, as Michel had told him Nirgal had done with him. He very much doubted that this had ever cured anybody of anything, but he did it anyway. Sitting for so long in such a posture, he had occasion to think about the brain plasticity treatments that Vlad and Ursula had administered to him after his stroke. Of course a stroke was a very different thing than a coma. But a change of mind was not necessarily a bad thing, if one’s mind was in pain.

More days passed without a change, each day slower and blanker and more fearful than the one before. The incubators in the Da Vinci labs had long since cooked up a full set of corrected Ann-specific DNA strands,

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