Darwin and Modern Science [68]
and at once gave a rationale of these facts. Genetic Variation is then primarily the consequence of additions to, or omissions from, the stock of elements which the species contains. The further investigation of the species-problem must thus proceed by the analytical method which breeding experiments provide.
In the nine years which have elapsed since Mendel's clue became generally known, progress has been rapid. We now understand the process by which a polymorphic race maintains its polymorphism. When a family consists of dissimilar members, given the numerical proportions in which these members are occurring, we can represent their composition symbolically and state what types can be transmitted by the various members. The difficulty of the "swamping effects of intercrossing" is practically at an end. Even the famous puzzle of sex-limited inheritance is solved, at all events in its more regular manifestations, and we know now how it is brought about that the normal sisters of a colour-blind man can transmit the colour-blindness while his normal brothers cannot transmit it.
We are still only on the fringe of the inquiry. It can be seen extending and ramifying in many directions. To enumerate these here would be impossible. A whole new range of possibilities is being brought into view by study of the interrelations between the simple factors. By following up the evidence as to segregation, indications have been obtained which can only be interpreted as meaning that when many factors are being simultaneously redistributed among the germ-cells, certain of them exert what must be described as a repulsion upon other factors. We cannot surmise whither this discovery may lead.
In the new light all the old problems wear a fresh aspect. Upon the question of the nature of Sex, for example, the bearing of Mendelian evidence is close. Elsewhere I have shown that from several sets of parallel experiments the conclusion is almost forced upon us that, in the types investigated, of the two sexes the female is to be regarded as heterozygous in sex, containing one unpaired dominant element, while the male is similarly homozygous in the absence of that element. (In other words, the ova are each EITHER female, OR male (i.e. non-female), but the sperms are all non-female.) It is not a little remarkable that on this point--which is the only one where observations of the nuclear processes of gameto-genesis have yet been brought into relation with the visible characteristics of the organisms themselves--there should be diametrical opposition between the results of breeding experiments and those derived from cytology.
Those who have followed the researches of the American school will be aware that, after it had been found in certain insects that the spermatozoa were of two kinds according as they contained or did not contain the accessory chromosome, E.B. Wilson succeeded in proving that the sperms possessing this accessory body were destined to form FEMALES on fertilisation, while sperms without it form males, the eggs being apparently indifferent. Perhaps the most striking of all this series of observations is that lately made by T.H. Morgan (Morgan, "Proc. Soc. Exp. Biol. Med." V. 1908, and von Baehr, "Zool. Anz." XXXII. page 507, 1908.), since confirmed by von Baehr, that in a Phylloxeran two kinds of spermatids are formed, respectively with and without an accessory (in this case, DOUBLE) chromosome. Of these, only those possessing the accessory body become functional spermatozoa, the others degenerating. We have thus an elucidation of the puzzling fact that in these forms fertilisation results in the formation of FEMALES only. How the males are formed--for of course males are eventually produced by the parthenogenetic females--we do not know.
If the accessory body is really to be regarded as bearing the factor for femaleness, then in Mendelian terms female is DD and male is DR. The eggs are indifferent and the spermatozoa are each male, OR female. But according to the evidence derived from a study of the
In the nine years which have elapsed since Mendel's clue became generally known, progress has been rapid. We now understand the process by which a polymorphic race maintains its polymorphism. When a family consists of dissimilar members, given the numerical proportions in which these members are occurring, we can represent their composition symbolically and state what types can be transmitted by the various members. The difficulty of the "swamping effects of intercrossing" is practically at an end. Even the famous puzzle of sex-limited inheritance is solved, at all events in its more regular manifestations, and we know now how it is brought about that the normal sisters of a colour-blind man can transmit the colour-blindness while his normal brothers cannot transmit it.
We are still only on the fringe of the inquiry. It can be seen extending and ramifying in many directions. To enumerate these here would be impossible. A whole new range of possibilities is being brought into view by study of the interrelations between the simple factors. By following up the evidence as to segregation, indications have been obtained which can only be interpreted as meaning that when many factors are being simultaneously redistributed among the germ-cells, certain of them exert what must be described as a repulsion upon other factors. We cannot surmise whither this discovery may lead.
In the new light all the old problems wear a fresh aspect. Upon the question of the nature of Sex, for example, the bearing of Mendelian evidence is close. Elsewhere I have shown that from several sets of parallel experiments the conclusion is almost forced upon us that, in the types investigated, of the two sexes the female is to be regarded as heterozygous in sex, containing one unpaired dominant element, while the male is similarly homozygous in the absence of that element. (In other words, the ova are each EITHER female, OR male (i.e. non-female), but the sperms are all non-female.) It is not a little remarkable that on this point--which is the only one where observations of the nuclear processes of gameto-genesis have yet been brought into relation with the visible characteristics of the organisms themselves--there should be diametrical opposition between the results of breeding experiments and those derived from cytology.
Those who have followed the researches of the American school will be aware that, after it had been found in certain insects that the spermatozoa were of two kinds according as they contained or did not contain the accessory chromosome, E.B. Wilson succeeded in proving that the sperms possessing this accessory body were destined to form FEMALES on fertilisation, while sperms without it form males, the eggs being apparently indifferent. Perhaps the most striking of all this series of observations is that lately made by T.H. Morgan (Morgan, "Proc. Soc. Exp. Biol. Med." V. 1908, and von Baehr, "Zool. Anz." XXXII. page 507, 1908.), since confirmed by von Baehr, that in a Phylloxeran two kinds of spermatids are formed, respectively with and without an accessory (in this case, DOUBLE) chromosome. Of these, only those possessing the accessory body become functional spermatozoa, the others degenerating. We have thus an elucidation of the puzzling fact that in these forms fertilisation results in the formation of FEMALES only. How the males are formed--for of course males are eventually produced by the parthenogenetic females--we do not know.
If the accessory body is really to be regarded as bearing the factor for femaleness, then in Mendelian terms female is DD and male is DR. The eggs are indifferent and the spermatozoa are each male, OR female. But according to the evidence derived from a study of the