The Cassandra Complex - Brian Stableford [34]
“Professor Miller doesn’t seem to have much sympathy for the notion that the four cities are an accurate parable of the human predicament,” Lisa told him.
“Perhaps he is insensitive to the deeper subtleties of the parable,” Chan suggested. “He tends to think of the mice in the central block as something separate from the cities, so when he speaks of Mouseworld as a parable, he only has in mind the population problem, but the population problem is not all there is to Mouseworld, any more than it is all there is to the human world. I am not saying, of course, that every other aspect of the human world is mirrored in the confusion of that magical H—but I do say that those with the eyes to see it will find more mirrors there than they might expect.”
“The models,” Lisa said, to demonstrate that she was on the ball. “Around the walls, the more or less healthy masses, but in the ghetto, the seriously sick.”
In the wake of the Human Genome Project, there had been a boom in the use of transgenic mice as “models” of every known human genetic-deficiency disease. All kinds of gene-based diseases that were difficult to investigate in living human patients could be inflicted on “knockout mice” by deliberately damaging the relevant gene in mouse embryos, which could then produce true-breeding populations of mice, all of whose members were victims. Where variant forms of a still-functional gene were responsible for pathological symptoms, the variant forms could be transplanted from humans into mice in place of the deleted native version, with only a little less trouble. The development of the diseases could be tracked much more closely in model mice because specimens could be killed and dissected at every relevant stage, and the populations also provided valuable preliminary testing grounds for possible treatments and cures.
“That’s right,” said Chan, bowing his head slightly to acknowledge her alacrity. “But you must follow the analogy farther.”
She tried. The evening sun, which was shining in a margin of clear sky but Ht abundant clouds from below, was filling the room with a peculiarly fiery light. Where it reflected from the transparent-plastic faces of the cages, it was more red than gold.
“You mean that the models are temporary residents in Mouseworld,” she ventured eventually. “The business is booming now, but it’ll be a short-term thing. As we find the treatments and the cures, the models will become obsolete—and in the human world too, the genetic-deficiency diseases will begin to disappear.”
“If only it were that simple,” Chan lamented. “Alas, we shall probably be required to keep the models long after their human analogues have become mercifully extinct. Already there are redundant models mingled with the others, mere library specimens sustained in case they should someday become necessary again. Naturally enough, you are thinking of the most obvious applications of the new technology—the battle against Huntington’s disease, Duchenne muscular dystrophy, phenylketonuria, and all the other crippling conditions our new model armies will allow us to defeat. Those models are, of course, the ones that wear their names with pride. But what of the others?”
He paused so she could prompt him, but she was still distracted by the temporary play of the unusual light as it filtered through the few portals left to it by Mouseworld’s architects. The pattern of the reflections that redirected the mellow beams into the corners