The Evolution of Modern Medicine [85]
in old, ill-equipped hospitals, that many surgeons feared to operate, and the general mortality in all surgical cases was very high. Believing that it was from outside that the germs came which caused the decomposition of wounds, just as from the atmosphere the sugar solution got the germs which caused the fermentation, a young surgeon in Glasgow, Joseph Lister, applied the principles of Pasteur's experiments to their treatment. From Lister's original paper[*] I quote the following: "Turning now to the question how the atmosphere produces decomposition of organic substances, we find that a flood of light has been thrown upon this most important subject by the philosophic researches of M. Pasteur, who has demonstrated by thoroughly convincing evidence that it is not to its oxygen or to any of its gaseous constituents that the air owes this property, but to minute particles suspended in it, which are the germs of various low forms of life, long since revealed by the microscope, and regarded as merely accidental concomitants of putrescence, but now shown by Pasteur to be its essential cause, resolving the complex organic compounds into substances of simpler chemical constitution, just as the yeast-plant converts sugar into alcohol and carbonic acid." From these beginnings modern surgery took its rise, and the whole subject of wound infection, not only in relation to surgical diseases, but to child-bed fever, forms now one of the most brilliant chapters in the history of preventive medicine.
[*] Lancet, March 16, 1867. [Cf. Camac: Epoch-making Contributions, etc., 1909, p. 7.--Ed.]
With the new technique and experimental methods, the discovery of the specific germs of many of the more important acute infections followed each other with bewildering rapidity: typhoid fever, diphtheria, cholera, tetanus, plague, pneumonia, gonorrhoea and, most important of all, tuberculosis. It is not too much to say that the demonstration by Koch of the "bacillus tuberculosis" (1882) is, in its far-reaching results, one of the most momentous discoveries ever made.
Of almost equal value have been the researches upon the protozoan forms of animal life, as causes of disease. As early as 1873, spirilla were demonstrated in relapsing fever. Laveran proved the association of haematozoa with malaria in 1880. In the same year, Griffith Evans discovered trypanosomes in a disease of horses and cattle in India, and the same type of parasite was found in the sleeping sickness. Amoebae were demonstrated in one form of dysentery, and in other tropical diseases protozoa were discovered, so that we were really prepared for the announcement in 1905, by Schaudinn, of the discovery of a protozoan parasite in syphilis. Just fifty years had passed since Pasteur had sent in his paper on "Lactic Acid Fermentation" to the Lille Scientific Society--half a century in which more had been done to determine the true nature of disease than in all the time that had passed since Hippocrates. Celsus makes the oft-quoted remark that to determine the cause of a disease often leads to the remedy,[*] and it is the possibility of removing the cause that gives such importance to the new researches on disease.
[*] "Et causae quoque estimatio saepe morbum solvit," Celsus, Lib. I, Prefatio.--Ed.
INTERNAL SECRETIONS
ONE of the greatest contributions of the nineteenth century to scientific medicine was the discovery of the internal secretions of organs. The basic work on the subject was done by Claude Bernard, a pupil of the great Magendie, whose saying it is well to remember--"When entering a laboratory one should leave theories in the cloakroom." More than any other man of his generation, Claude Bernard appreciated the importance of experiment in practical medicine. For him the experimental physician was the physician of the future-- a view well borne out by the influence his epoch-making work has had on the treatment of disease. His studies on the glycogenic functions of the liver opened the way for the modern fruitful researches on the internal secretions
[*] Lancet, March 16, 1867. [Cf. Camac: Epoch-making Contributions, etc., 1909, p. 7.--Ed.]
With the new technique and experimental methods, the discovery of the specific germs of many of the more important acute infections followed each other with bewildering rapidity: typhoid fever, diphtheria, cholera, tetanus, plague, pneumonia, gonorrhoea and, most important of all, tuberculosis. It is not too much to say that the demonstration by Koch of the "bacillus tuberculosis" (1882) is, in its far-reaching results, one of the most momentous discoveries ever made.
Of almost equal value have been the researches upon the protozoan forms of animal life, as causes of disease. As early as 1873, spirilla were demonstrated in relapsing fever. Laveran proved the association of haematozoa with malaria in 1880. In the same year, Griffith Evans discovered trypanosomes in a disease of horses and cattle in India, and the same type of parasite was found in the sleeping sickness. Amoebae were demonstrated in one form of dysentery, and in other tropical diseases protozoa were discovered, so that we were really prepared for the announcement in 1905, by Schaudinn, of the discovery of a protozoan parasite in syphilis. Just fifty years had passed since Pasteur had sent in his paper on "Lactic Acid Fermentation" to the Lille Scientific Society--half a century in which more had been done to determine the true nature of disease than in all the time that had passed since Hippocrates. Celsus makes the oft-quoted remark that to determine the cause of a disease often leads to the remedy,[*] and it is the possibility of removing the cause that gives such importance to the new researches on disease.
[*] "Et causae quoque estimatio saepe morbum solvit," Celsus, Lib. I, Prefatio.--Ed.
INTERNAL SECRETIONS
ONE of the greatest contributions of the nineteenth century to scientific medicine was the discovery of the internal secretions of organs. The basic work on the subject was done by Claude Bernard, a pupil of the great Magendie, whose saying it is well to remember--"When entering a laboratory one should leave theories in the cloakroom." More than any other man of his generation, Claude Bernard appreciated the importance of experiment in practical medicine. For him the experimental physician was the physician of the future-- a view well borne out by the influence his epoch-making work has had on the treatment of disease. His studies on the glycogenic functions of the liver opened the way for the modern fruitful researches on the internal secretions